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. 2022 Mar 4;9:72. doi: 10.1038/s41597-022-01159-y

Table 2.

Statistics related to the performance evaluation of three SDAs for single drugs using FAERS data.

Citation SDA Resource union Positive controls: 52,637 Negative controls: 12,141 Resource intersection Positive controls: 12,318 Negative controls: 12,141
AUC (95% CI) AUC (95% CI)
Evans et al., 2001 34 Proportional Reporting Ratio (PRR)

0.5791

(0.5746, 0.5835)

0.5959

(0.5884, 0.6033)
DuMouchel, 1999 35 EBGM (Empirical Bayes Geometric Mean)

0.6308

(0.6259, 0.6356)

0.6593

(0.6510, 0.6675)
Bate et al., 1998 36 BCPNN (Bayesian Confidence Propagation Neural Network)

0. 7063

(0.7008, 0.7117)

0.7495

(0.7401, 0.7588)

AUC, area under the receiver operating characteristic curve; Score+, median signal score for the set of positive controls; Score−, median signal score for the set of negative controls.