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. 2022 Mar 4;12:3582. doi: 10.1038/s41598-022-07621-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The relative change (the change in the lens-wearing eye relative to the change in the fellow eye) in vitreous chamber depth (VCD, A) and refractive error (RE, B) after wearing − 5D lenses for 4 weeks, either continuously or with interruptions. Triangles show individual animals, and bars represent the average for each group. RE was measured in 6 out of the 13 animals for the control group. n.s. Not significant; **p < 0.01; ***p < 0.001.