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. 2022 Mar 4;13(3):207. doi: 10.1038/s41419-022-04612-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — A Hsa_circRNA_0012138 expression by RT-qPCR analysis. B Hsa_miR-651-5p expression by RT-qPCR analysis. C FGB expression by RT-qPCR analysis. D FGB expression by western blot analysis. E Quantification of protein band of FGB by grayscale analysis. F MicroRNAs predicted to interact with hsa_circRNA_0012138. G Gene Ontology enrichment analysis in microRNAs targeted genes. H Kyoto Encyclopedia of Genes and Genomes enrichment analysis in microRNAs targeted genes. Samples were obtained from postoperative specimens of three group of patients. Normal: carcinoma-adjacent normal tissues of patients undergoing radical nephrectomy; Moderate group: obstructive hydronephrosis kidney tissues of patients undergoing hydronephroctomy; Severe group: obstructive hydronephrosis kidney tissues of patients undergoing hydronephroctomy, with longer obstruction time, less unilateral residual GFR and thinner cortical thickness than Group A. *p < 0.05, Severe group or Moderate group vs. Normal group.