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. 2022 Mar 4;12:3590. doi: 10.1038/s41598-022-07530-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ecDNA and expression of inhibitory immune checkpoint genes and TMB. (a) Expression of inhibitory immune checkpoint genes in tumors with ecDNA and without ecDNA. Wilcoxon test P values are shown. (b) Tumor mutation burden (TMB) difference in different types of tumors with and without ecDNA. Wilcoxon test P values are shown. ns: P > 0.05, *: P ≤ 0.05, **: P ≤ 0.01, ***: P ≤ 0.001, ****: P ≤ 0.0001. TCGA cancer type acronyms: STAD (stomach adenocarcinoma), SKCM (skin cutaneous melanoma), HNSC (head and neck squamous cell carcinoma), LUAD (lung adenocarcinoma), BLCA (bladder urothelial carcinoma), BRCA (breast invasive carcinoma), ESCA (esophageal carcinoma), GBM (glioblastoma multiforme).