Table 1.

The demographic and clinical characteristics of FD patients

	Trial 1	Trial 2
Gender (male/female)	164/388	63/130
Age (year)	37.01 ± 13.48	39.55 ± 15.19
Body mass index (kg/m2)	20.82 ± 2.43	20.86 ± 2.48
Education level (1/2/3/4/5)	1/33/199/286/33	4/16/43/107/23
Marriage status (unmarried/married)	184/368	74/119
Duration (month)	67.71 ± 62.73	94.91 ± 93.40
Subtype of disease (PDS/EPS)	355/198	111/82
Epigastric pain score	4.47 ± 3.62	4.23 ± 3.00
Epigastric discomfort score	5.40 ± 3.51	5.85 ± 2.86
Epigastric burning score	1.55 ± 2.65	1.45 ± 2.37
Chest burning score	0.81 ± 2.14	0.94 ± 2.20
Epigastric spasmodic pain score	0.76 ± 1.97	0.95 ± 2.30
Chest pain score	0.61 ± 1.82	0.78 ± 1.94
Irregular meals score	3.53 ± 3.47	2.66 ± 3.40
Reflux of acid/bitterness score	2.91 ± 3.35	2.89 ± 3.06
Epigastric fullness/slow digestion score	6.23 ± 3.48	6.36 ± 3.12
Epigastric pressure score	1.11 ± 2.36	1.62 ± 2.90
Epigastric bloating score	5.59 ± 3.57	5.35 ± 3.32
Nausea score	1.57 ± 2.74	2.30 ± 3.05
Belching score	4.01 ± 3.41	3.46 ± 3.37
Vomiting score	0.58 ± 1.87	0.77 ± 2.13
Halitosis score	0.95 ± 2.52	1.98 ± 3.08
NDSI score	40.08 ± 16.66	41.56 ± 19.97
Interference domain score	76.84 ± 11.12	80.17 ± 16.38
Knowledge/control domain score	72.67 ± 11.06	75.19 ± 15.98
Eat/drink domain score	71.93 ± 12.90	69.64 ± 17.95
Sleep/disturb domain score	75.45 ± 16.10	77.62 ± 19.83
NDLQI score	74.22 ± 10.60	75.65 ± 14.28

The NDSI score contains 15 sub-scores, which measured the severity of 15 common symptoms in patients with functional dyspepsia. The NDLQI score contains 4 dimensions of quality of life, including interference, knowledge/control, eat/drink and sleep/disturb. Abbreviation: 1/2/3/4/5 illiterate/primary school/middle school/high school/college and above, PDS/EPS postprandial distress syndrome/epigastric pain syndrome, NDSI Nepean Dyspepsia Symptom Index, NDLQI Nepean Dyspepsia Life Quality Index