Figure 2. Meflin⁺ cancer-associated fibroblasts (CAFs) constitute a CAF subset distinct from known CAF subsets.

t-distributed stochastic neighbor embedding (tSNE) plots obtained by analysis of a single-cell RNA sequencing dataset showed differential expression of Meflin in ACTA2⁺, IL6⁺, and HLA-DRA⁺ CAF subsets, which represent myCAFs, iCAFs, and apCAFs, respectively, of human non-small cell lung cancer and distal non-malignant lung samples (left panels). Density plots (middle panels) and violin/box/scatter plots (right panels) derived from gene expression data of the single-cell analysis showed that Meflin⁺ CAFs constitute a unique CAF subset distinct from myCAF, iCAFs, and apCAFs.

Source data are available for this figure.