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. 2021 Nov 24;14:272–289. doi: 10.1016/j.bioactmat.2021.11.019

Fig. 10.

Fig. 10

Schematic diagram showing the antibacterial mechanism of felodipine in combination with gentamicin against MRSA and persisters. Low dose of felodipine reduce the TCA cycle and protein level of aacA-aphD. Besides, it binds to the active site of ClpP subunit, leading to protein degradation.