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. 2022 Mar 5;434(11):167530. doi: 10.1016/j.jmb.2022.167530

Figure 3.

Figure 3

A summary of SARS-CoV-2/human interactome prediction. (a) A network overview of the full interactome of human/SARS-CoV-2 protein pairs, with SARS-CoV-2 proteins colored red and human proteins colored blue. (b) A bar chart of the number of predicted interactions involving each SARS-CoV-2 protein. Proteins which were not predicted to have any interactions were excluded. (c) A superposition of a dimer model of the top-ranked SARS-CoV-2 Spike (in red) and Human ACE2 (in blue) interaction on its dimer template structure (PDB 6ACG; chain D in cyan, chain C in yellow). (d) A superposition of a dimer model of the SARS-CoV-2 nsp3 macrodomain (in red) and human PARP15 macrodomain (in blue) on its dimer template structure (PDB 2W2G; chain A in cyan, chain B in yellow). (e) A superposition of a dimer model of a domain of the SARS-CoV-2 nsp3 (in red) and human NEDD8 (in blue) on its dimer template structure (PDB 5WFI; chain C in cyan, chain A in yellow). (f) A superposition of a dimer model of a domain of the SARS-CoV-2 nsp3 (in red) and human UBD (in blue) on its dimer template structure (PDB 6BI8; chain C in cyan, chain A in yellow).