Table 3.
Biological processes enriched in the peripheral blood in term labor compared to term without labor
| Biological process | Count | Size | Odds ratio | q | p | Significant in PPROMa |
|---|---|---|---|---|---|---|
| Leukocyte activation | 17 | 1288 | 4.8 | 0.001 | 1.44E-06 | 1 |
| Immune response | 22 | 2187 | 3.9 | 0.001 | 2.68E-06 | 1 |
| Cell activation | 17 | 1447 | 4.2 | 0.001 | 7.00E-06 | 1 |
| Immune system process | 26 | 3156 | 3.3 | 0.001 | 9.69E-06 | 1 |
| Immune effector process | 15 | 1253 | 4.2 | 0.002 | 2.21E-05 | 1 |
| Regulation of immune system process | 17 | 1580 | 3.8 | 0.002 | 2.22E-05 | 1 |
| Leukocyte mediated immunity | 12 | 850 | 4.8 | 0.003 | 3.49E-05 | 1 |
| Adaptive immune response | 10 | 621 | 5.3 | 0.004 | 5.74E-05 | 1 |
| Positive regulation of cellular carbohydrate metabolic process | 4 | 62 | 20.8 | 0.004 | 6.67E-05 | 0 |
| Inflammatory response | 11 | 787 | 4.6 | 0.005 | 8.46E-05 | 0 |
| Leukocyte activation involved in immune response | 10 | 709 | 4.6 | 0.009 | 0.000171 | 1 |
| Cell activation involved in immune response | 10 | 713 | 4.6 | 0.009 | 0.000179 | 1 |
| Positive regulation of carbohydrate metabolic process | 4 | 84 | 15 | 0.01 | 0.000218 | 0 |
| Lymphocyte activation | 10 | 737 | 4.4 | 0.01 | 0.000234 | 0 |
| Neutrophil activation | 8 | 497 | 5.2 | 0.013 | 0.000339 | 1 |
| Granulocyte activation | 8 | 504 | 5.1 | 0.014 | 0.000372 | 1 |
| Positive regulation of glucose metabolic process | 3 | 42 | 22.8 | 0.014 | 0.000432 | 0 |
| Myeloid leukocyte activation | 9 | 656 | 4.4 | 0.014 | 0.000457 | 1 |
| T cell cytokine production | 3 | 43 | 22.2 | 0.014 | 0.000464 | 0 |
| Lymphocyte activation involved in immune response | 5 | 185 | 8.4 | 0.014 | 0.000484 | 0 |
| T-helper 1 type immune response | 3 | 44 | 21.7 | 0.014 | 0.000496 | 1 |
| Regulation of immune response | 11 | 971 | 3.7 | 0.014 | 0.000522 | 1 |
| T cell activation involved in immune response | 4 | 108 | 11.6 | 0.014 | 0.000568 | 0 |
| B cell activation | 6 | 305 | 6.2 | 0.017 | 0.000701 | 0 |
| Regulation of glucose metabolic process | 4 | 120 | 10.4 | 0.02 | 0.000843 | 0 |
| Defense response | 15 | 1752 | 2.9 | 0.02 | 0.000907 | 0 |
| Lymphocyte mediated immunity | 6 | 328 | 5.7 | 0.022 | 0.001022 | 1 |
| Positive regulation of immune system process | 11 | 1058 | 3.4 | 0.022 | 0.001061 | 1 |
| Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 6 | 331 | 5.7 | 0.022 | 0.001071 | 1 |
| Response to reactive oxygen species | 5 | 225 | 6.9 | 0.023 | 0.001167 | 0 |
| Regulation of mitotic sister chromatid separation | 3 | 61 | 15.3 | 0.024 | 0.001293 | 0 |
| Mitotic sister chromatid separation | 3 | 64 | 14.6 | 0.027 | 0.001485 | 0 |
| Neutrophil degranulation | 7 | 483 | 4.6 | 0.027 | 0.001499 | 1 |
| Neutrophil activation involved in immune response | 7 | 486 | 4.5 | 0.027 | 0.001553 | 1 |
| Regulation of chromosome separation | 3 | 66 | 14.1 | 0.027 | 0.001623 | 0 |
| Negative regulation of protein serine/threonine kinase activity | 4 | 144 | 8.6 | 0.027 | 0.001656 | 0 |
| Neutrophil mediated immunity | 7 | 497 | 4.4 | 0.028 | 0.001764 | 1 |
| Regulation of cellular carbohydrate metabolic process | 4 | 147 | 8.4 | 0.028 | 0.001786 | 0 |
| T cell differentiation involved in immune response | 3 | 70 | 13.3 | 0.028 | 0.001922 | 0 |
| Positive regulation of small molecule metabolic process | 4 | 150 | 8.2 | 0.028 | 0.001923 | 0 |
| Regulation of mitotic sister chromatid segregation | 3 | 72 | 12.9 | 0.03 | 0.002084 | 0 |
| Negative regulation of kinase activity | 5 | 264 | 5.8 | 0.033 | 0.002353 | 0 |
| Leukocyte degranulation | 7 | 533 | 4.1 | 0.036 | 0.002614 | 1 |
| Regulation of adaptive immune response | 4 | 166 | 7.4 | 0.037 | 0.002777 | 0 |
| Myeloid cell activation involved in immune response | 7 | 544 | 4 | 0.038 | 0.002929 | 1 |
| Myeloid leukocyte mediated immunity | 7 | 551 | 4 | 0.039 | 0.003144 | 1 |
| Response to bacterium | 8 | 704 | 3.6 | 0.039 | 0.00316 | 0 |
| Regulation of B cell activation | 4 | 173 | 7.1 | 0.039 | 0.003221 | 0 |
| Regulation of sister chromatid segregation | 3 | 84 | 11 | 0.039 | 0.003231 | 0 |
| Negative regulation of transferase activity | 5 | 291 | 5.3 | 0.041 | 0.003574 | 0 |
| Cellular carbohydrate metabolic process | 5 | 292 | 5.3 | 0.041 | 0.003627 | 0 |
| Positive regulation of immune response | 8 | 721 | 3.5 | 0.041 | 0.003653 | 1 |
| Monosaccharide metabolic process | 5 | 295 | 5.2 | 0.042 | 0.003788 | 0 |
| Regulation of response to external stimulus | 10 | 1081 | 2.9 | 0.046 | 0.004264 | 0 |
| Regulation of response to stimulus | 25 | 4308 | 2.1 | 0.046 | 0.004322 | 0 |
| Chromosome separation | 3 | 94 | 9.7 | 0.046 | 0.004434 | 0 |
| Negative regulation of inflammatory response | 4 | 190 | 6.4 | 0.046 | 0.004497 | 0 |
| Defense response to bacterium | 5 | 310 | 5 | 0.046 | 0.004671 | 0 |
| Leukocyte proliferation | 5 | 310 | 5 | 0.046 | 0.004671 | 0 |
| B cell proliferation | 3 | 97 | 9.4 | 0.047 | 0.004841 | 0 |
| Regulation of carbohydrate biosynthetic process | 3 | 98 | 9.3 | 0.048 | 0.004981 | 0 |
| Innate immune response | 9 | 943 | 3 | 0.052 | 0.005515 | 0 |
| T cell mediated immunity | 3 | 103 | 8.9 | 0.053 | 0.00572 | 1 |
| Cytokine production involved in immune response | 3 | 104 | 8.8 | 0.053 | 0.005875 | 0 |
| Immune response-regulating cell surface receptor signaling pathway | 6 | 468 | 4 | 0.053 | 0.005976 | 0 |
| Regulation of chromosome segregation | 3 | 105 | 8.7 | 0.053 | 0.006033 | 0 |
| Immune response-regulating signaling pathway | 6 | 471 | 3.9 | 0.053 | 0.006161 | 0 |
| Regulation of carbohydrate metabolic process | 4 | 208 | 5.9 | 0.053 | 0.00618 | 0 |
| Negative regulation of phosphorylation | 6 | 473 | 3.9 | 0.053 | 0.006286 | 0 |
| Regulated exocytosis | 8 | 793 | 3.2 | 0.054 | 0.006439 | 0 |
| Glucose metabolic process | 4 | 213 | 5.7 | 0.055 | 0.006713 | 0 |
| Defense response to other organism | 10 | 1154 | 2.7 | 0.055 | 0.006716 | 0 |
| Interferon-gamma production | 3 | 113 | 8.1 | 0.059 | 0.007387 | 0 |
| Fc receptor signaling pathway | 4 | 220 | 5.5 | 0.06 | 0.007509 | 0 |
| Carboxylic acid transport | 5 | 349 | 4.4 | 0.06 | 0.007639 | 0 |
| Organic acid transport | 5 | 352 | 4.3 | 0.061 | 0.007911 | 0 |
| Response to stress | 23 | 4047 | 2 | 0.066 | 0.008709 | 0 |
| Response to cytokine | 10 | 1203 | 2.6 | 0.066 | 0.008903 | 0 |
| Fc-gamma receptor signaling pathway | 3 | 121 | 7.5 | 0.066 | 0.008907 | 0 |
| Regulation of leukocyte chemotaxis | 3 | 124 | 7.3 | 0.07 | 0.009521 | 0 |
| Secretion by cell | 11 | 1420 | 2.5 | 0.073 | 0.010082 | 0 |
| Negative regulation of protein kinase activity | 4 | 242 | 5 | 0.075 | 0.010409 | 0 |
| Positive regulation of response to biotic stimulus | 4 | 248 | 4.9 | 0.079 | 0.01131 | 0 |
| Leukocyte differentiation | 6 | 537 | 3.4 | 0.079 | 0.01136 | 0 |
| Negative regulation of intracellular signal transduction | 6 | 543 | 3.4 | 0.083 | 0.011952 | 0 |
| Hexose metabolic process | 4 | 253 | 4.8 | 0.083 | 0.012098 | 0 |
| Response to hydrogen peroxide | 3 | 138 | 6.6 | 0.085 | 0.012708 | 0 |
| Monocarboxylic acid catabolic process | 3 | 138 | 6.6 | 0.085 | 0.012708 | 0 |
| Export from cell | 11 | 1471 | 2.4 | 0.085 | 0.012923 | 0 |
| Negative regulation of defense response | 4 | 261 | 4.6 | 0.088 | 0.013431 | 0 |
| Regulation of response to biotic stimulus | 5 | 404 | 3.8 | 0.089 | 0.013767 | 0 |
| Exocytosis | 8 | 910 | 2.7 | 0.09 | 0.014096 | 0 |
| Regulation of defense response | 7 | 735 | 2.9 | 0.091 | 0.014416 | 0 |
| Cellular response to cytokine stimulus | 9 | 1113 | 2.5 | 0.095 | 0.015419 | 0 |
| Carbohydrate transport | 3 | 149 | 6.1 | 0.095 | 0.015592 | 0 |
| Carboxylic acid transmembrane transport | 3 | 149 | 6.1 | 0.095 | 0.015592 | 0 |
| Regulation of leukocyte activation | 6 | 578 | 3.2 | 0.095 | 0.015842 | 0 |
| Organic acid transmembrane transport | 3 | 150 | 6 | 0.095 | 0.015871 | 0 |
| Negative regulation of cellular protein metabolic process | 9 | 1121 | 2.5 | 0.095 | 0.01609 | 0 |
| Regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 3 | 151 | 6 | 0.095 | 0.016153 | 0 |
| Response to other organism | 11 | 1524 | 2.3 | 0.095 | 0.016491 | 0 |
| Response to external biotic stimulus | 11 | 1526 | 2.3 | 0.095 | 0.016639 | 0 |
| Negative regulation of response to external stimulus | 5 | 424 | 3.6 | 0.095 | 0.016641 | 0 |
| Production of molecular mediator of immune response | 4 | 279 | 4.3 | 0.095 | 0.016764 | 0 |
| Lymphocyte proliferation | 4 | 280 | 4.3 | 0.095 | 0.016963 | 0 |
| Positive regulation of response to stimulus | 15 | 2392 | 2 | 0.095 | 0.01711 | 0 |
| Negative regulation of phosphate metabolic process | 6 | 591 | 3.1 | 0.095 | 0.017489 | 0 |
| Mononuclear cell proliferation | 4 | 283 | 4.3 | 0.095 | 0.017569 | 0 |
| Negative regulation of phosphorus metabolic process | 6 | 592 | 3.1 | 0.095 | 0.01762 | 0 |
| Import across plasma membrane | 3 | 157 | 5.7 | 0.095 | 0.017903 | 0 |
| Negative regulation of protein phosphorylation | 5 | 433 | 3.5 | 0.095 | 0.018056 | 0 |
| Immune response-activating cell surface receptor signaling pathway | 5 | 436 | 3.5 | 0.096 | 0.018545 | 0 |
| Immune response-activating signal transduction | 5 | 436 | 3.5 | 0.096 | 0.018545 | 0 |
| Secretion | 11 | 1557 | 2.2 | 0.097 | 0.019064 | 0 |
| Mitotic sister chromatid segregation | 3 | 161 | 5.6 | 0.097 | 0.019126 | 0 |
| Response to biotic stimulus | 11 | 1558 | 2.2 | 0.097 | 0.019146 | 0 |
| Cellular response to reactive oxygen species | 3 | 162 | 5.6 | 0.097 | 0.019439 | 0 |
| Cell surface receptor signaling pathway | 18 | 3122 | 1.9 | 0.097 | 0.019617 | 0 |
| Response to oxidative stress | 5 | 443 | 3.4 | 0.097 | 0.019719 | 0 |
| Regulation of mitotic nuclear division | 3 | 163 | 5.5 | 0.097 | 0.019755 | 0 |
| Cytokine-mediated signaling pathway | 7 | 787 | 2.7 | 0.098 | 0.020221 | 0 |
a0, not significant; 1, significant.