Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 1;15:1421–1436. doi: 10.2147/JIR.S345517

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 Zhu et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

Analgesic Effect of iMSC-sEVs on Rat Tendinopathy Model. (A) Diagram showing timing for the model establishment and iMSC-sEVs treatment. Pain-related behaviors were assessed once per week for 5 weeks and histopathological changes were evaluated at 5 weeks after model establishment. (B) Ultrasonogram of rat’s right leg (anterior view) around the quadriceps tendon showing quadriceps (Q) and femur (F). (C) Ultrasonogram showing the relative position of needle (white triangles) used to inject 4% carrageenan (100 μL bolus) solution around the quadriceps tendon. Asterisks (white) in (B and C) indicate the position of the quadriceps tendon. Pain-related behaviors were performed by using PWT (D) and SWB (E) reversal (%) up to 4 weeks after tendinopathy model establishment. PWT (F) and SWB (G) reversal (%) up to 4 weeks after tendinopathy model establishment. N = 5 rats for each group. SWB = static weight bearing; PWT = hind-paw withdrawal threshold; Data are presented as mean ± SD. *P < 0.05. **P < 0.01. ns indicates no significant difference.