Table 3.
Differences in weight and biomarker outcomes between intervention groups
| DPP-only Mean (SD) | DPP + HT Mean (SD) | Difference in change between groupsa | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||
| n | Baseline | n | Post-Intervention | Change | n | Baseline | n | Post-intervention | Change | Mean (95% CI) | |
| Weight (kg) | 23 | 95.8 (17.0) | 19 | 87.7 (13.2) | −5.0 (4.7) | 27 | 89.1 (15.6) | 22 | 82.9 (16.5) | −4.9 (3.7) | −0.3 (−2.9, 2.3) |
| BMI (kg/m2) | 23 | 36.1 (5.6) | 19 | 33.6 (5.2) | −1.9 (1.7) | 27 | 33.8 (4.7) | 22 | 31.4 (5.1) | −1.9 (1.3) | −0.1 (−1.1, 0.9) |
| Triglycerides (mg/dL) | 23 | 114.6 (32.9) | 19 | 120.7 (55.4) | 3.3 (50.3) | 27 | 121.1 (67.1) | 21 | 125.3 (65.8) | 1.0 (38.8) | −0.7 (−28.5, 27.1) |
| Total cholesterol (mg/dL) | 23 | 197.2 (40.0) | 19 | 196.4 (29.9) | 3.4 (16.5) | 27 | 209.4 (44.1) | 21 | 205.5 (41.4) | −4.2 (24.4) | −3.5 (−15.7, 8.7) |
| HDL (mg/dL) | 23 | 62.3 (12.1) | 19 | 63.4 (10.9) | 0.0 (8.4) | 27 | 62.5 (12.1) | 21 | 58.8 (10.2) | −3.3 (7.4) | −3.7 (−8.3, 0.9) |
| LDL (mg/dL) | 23 | 112.0 (38.2) | 19 | 108.8 (25.7) | 2.7 (17.4) | 27 | 122.6 (37.9) | 21 | 121.6 (35.0) | −1.1 (18.3) | 0.7 (−9.1, 10.5) |
| VLDL (mg/dL) | 23 | 22.9 (6.6) | 19 | 24.2 (11.1) | 0.7 (10.1) | 27 | 24.3 (13.4) | 21 | 25.1 (13.2) | 0.2 (7.8) | −0.2 (−5.7, 5.4) |
| HbA1c (%) | 23 | 5.6 (0.4) | 18 | 5.5 (0.4) | −0.1 (0.2) | 27 | 5.5 (0.3) | 21 | 5.5 (0.2) | −0.1 (0.2) | 0.0 (−0.1, 0.1) |
| Fasting glucose (mg/dL) | 23 | 97.0 (10.3) | 19 | 93.2 (13.6) | −3.6 (16.2) | 27 | 97.1 (6.4) | 21 | 97.2 (5.9) | 0.6 (7.0) | 4.5 (−2.1, 11.2) |
| Fasting insulin (mIU/L) | 23 | 16.8 (7.8) | 19 | 14.5 (7.8) | −2.5 (6.7) | 27 | 16.7 (8.2) | 21 | 13.1 (6.5) | −4.5 (5.3) | −1.8 (−5.1, 1.5) |
| HOMA-IR | 23 | 1.6 (0.8) | 19 | 1.4 (0.9) | −0.3 (0.7) | 27 | 1.6 (0.8) | 21 | 1.3 (0.6) | −0.4 ( 0.7) | −0.1 (−0.5, 0.3) |
| Adiponectin (μg/ml) | 23 | 9.4 (4.9) | 18 | 10.8 (5.8) | 1.0 (2.7) | 27 | 11.2 (5.7) | 21 | 11.4 (4.9) | 0.2 (2.6) | −0.6 (−2.2, 1.1) |
| CRP (mg/L) | 23 | 7.6 (6.4) | 19 | 6.0 (6.2) | −1.3 (5.6) | 27 | 4.6 (4.4) | 21 | 3.8 (2.7) | −0.9 (3.1) | −0.9 (−3.2, 1.5) |
| IGF-1 (ng/ml) | 23 | 104.6 (22.7) | 19 | 110.4 (28.4) | 2.9 (18.5) | 27 | 134.1 (42.4) | 20 | 143.1 (45.7) | 10.7 (16.9) | 7.6 (−5.0, 20.3) |
| IGF-2 (ng/ml) | 23 | 652.5 (162.8) | 17 | 630.8 (116.5) | −24.8 (158.3) | 27 | 803.5 (370.9) | 19 | 675.7 (203.8) | −124.9 (303.3) | −1.7 (−100.0, 96.7) |
| IGFBP-2 (ng/ml) | 23 | 193.9 (84.5) | 18 | 225.4 (131.0) | 33.3 (90.2) | 27 | 202.5 (136.4) | 19 | 257.9 (163.8) | 65.8 (91.2) | 32.5 (−29.0, 93.9) |
a.
Calculated using ANCOVA, adjusted for baseline. DPP = Diabetes Prevention Plan, HT = Hunger Training