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. 2022 Mar 5;8:99. doi: 10.1038/s41420-022-00902-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A, B NSUN5 binds to FTH1 and FTL mRNA in bone marrow-derived stem cells (BMSCs), as revealed by RNA immunoprecipitation (RIP), **p < 0.05. C, D NSUN5 overexpression increased the expression levels of FTH1 and FTL (C), whereas both ferritin subunits were downregulated by si-NSUN5 (D), as determined by western blotting. *p < 0.05. E NSUN5, FTH1, and FTL co-localized in the cytoplasm of BMSCs, as revealed by immunofluorescence analysis, *p < 0.05. F FTH1 and FTL overexpression attenuated the erastin-induced increase in total iron concentrations, *p < 0.05. G, H Erastin-induced ROS production (G) and lipid peroxidation (H) were attenuated by FTH1 and FTL overexpression in BMSCs. *p < 0.05 (A–H).