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. 2022 Mar 5;8:101. doi: 10.1038/s41420-022-00899-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A rhJAG1 (0.25 ng/mL) or rhFASLG (0.25 ng/mL) treatment promotes NOTCH1 signaling activation. B NOTCH signaling pathway activation analysis by cleavage NOTCH1 expression under rhJAG1 or rhFASLG treatment. C Knockdown of JAG1 or NOTCH1 by shRNA suppresses NOTCH1-ICD cleavage. D The CSC sphere formation assay in JAG1- or NOTCH1-silenced SAS cells. E, F JAG1 Kaplan–Meier plots of OS for the Taiwanese OSCC cohort (E, GSE37991) and the TCGA-HNSC cohort (F).