Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 7;18(4):1695–1705. doi: 10.7150/ijbs.64982

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The author(s)

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

PMC Copyright notice

The regulation of glutamine metabolism in ferroptosis. After entering the cell via the ASCT2, Gln can be degraded and provide a precursor for TCA and PUFAs biosynthesis. System Xc^- inputs cysteine to synthesize GSH and exchange Glu at the same time. GPX4 utilizes GSH to eliminate lipid peroxides that participate in ferroptosis. GCLC maintains the Glu pool homeostasis under cystine starvation by mediating the synthesis of γ-glutamine peptide, thereby limiting the accumulation of Glu and protecting against ferroptosis. Abbreviations: ASCT2: solute carrier family 1A5 transporter; Gln: Glutamine; Glu: glutamate; GLS: glutaminase; GDH: glutamate dehydrogenase; GOT1: aspartate aminotransferase 1; TCA: tricarboxylic acid; PUFAs: polyunsaturated fatty acids; system Xc^-: Cystine-glutamate antiporter transport system; GSH: glutathione; GPX4: glutathione peroxidase 4; GCLC: glutamate-cysteine ligase catalytic subunit.