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. 2022 Jan 24;18(4):1491–1507. doi: 10.7150/ijbs.69351

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CircDVL1 is decreased in human ccRCC tissues and correlates with miR-412a-3p and PCDH7. (A) The expression of circDVL1 in 18 matched ccRCC and adjacent normal tissue samples was tested by RT-qPCR. (B) The expression of miR-412-3p was carried out by performing RT-qPCR assays in 18 matched ccRCC tumors and adjacent normal tissue. (C) The levels of PCDH7 in ccRCC tumor and adjacent normal tissues were measured using RT-qPCR (n = 18). (D-F) Pearson correlation analysis between circDVL1, miR-412-3p and PCDH7 expression in 18 ccRCC samples. (G) Schematic illustration of the mechanism through which circDVL1 inhibits ccRCC progression via regulating the circDVL1/miR-412-3P/PCDH7 pathway.