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. 2022 Jan 16;18(4):1347–1362. doi: 10.7150/ijbs.67974

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LncRNA-COX2 inhibits fibrogenesis in epidural fibroblasts. (A) Basal LncRNA-COX2 expression in fibroblasts treated with TGF-β or not and (B) epidural tissues from surgical site and normal region of mice. qRT-PCR analysis of the expression of LncRNA-COX2 (C), Collagen I (D), α-SMA (E) in fibroblasts after transfection of LncRNA-COX2. (F) Immunofluorescence analysis of collagen I and α-SMA expression in TGF-β-cultured fibroblasts treated with LncRNA-COX2. (G) EdU analysis showing proliferative fibroblasts after TGF-β or LncRNA-COX2 treatment. Scale bar = 50 μm. (H) Quantitative analysis of proliferative fibroblasts in indicated groups. (I) Transwell assay showing migrated fibroblasts after TGF-β or LncRNA-COX2 treatment. Scale bar = 100 μm. (J) Quantitative analysis of migrated fibroblasts in indicated groups. *P<0.05.