Silencing LncRNA-COX2 promotes fibroblasts activation after EGR1 is suppressed. qRT-PCR analysis of EGR1 (A), Collagen I (B), α-SMA (C) in fibroblasts after EGR1 or LncRNA-COX2 inhibition. (D) Western blot analysis of EGR1, Collagen I, α-SMA in fibroblasts after EGR1 or LncRNA-COX2 inhibition. (E) Immunofluorescence analysis of collagen I and α-SMA expression in cultured fibroblasts knockdown of EGR1 or LncRNA-COX2. EdU assay (F) and Transwell assay (H) of fibroblasts in indicated groups. (G) Quantitative analysis of proliferative cells of (F). (I) Quantitative analysis of migrated cells of (H). #P<0.05, **P<0.01. Difference was analyzed by one-way ANOVA.