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. 2022 Jan 16;18(4):1347–1362. doi: 10.7150/ijbs.67974

Figure 4.

Figure 4

Degree of epidural fibrosis is markedly decreased after LncRNA-COX2 treatment. (A) Axial image of thoracic vertebrae in mice. Scale bar: 500μm. HE staining of representative images of the vertebrae morphology showing epidural wound injury site after laminectomy in different groups at the time of 3 days (B), 1 week (D), 4 weeks (F). Scale bar: 200 μm. Grades of epidural fibrosis in different groups at the time of 3 days (C), 1 week (E), 4 weeks (G) (n = 10). *P<0.05. **P<0.01. (H) Histological assessment of fibroblast infiltration at 3 days, 1 week and four weeks post-operation by HE staining analysis. Scale bar: 50 μm. (I) Fibroblast infiltration grades in epidural tissues in control group, LV-control group and LV- LncRNA-COX2 group at three different times (n = 10). *P<0.05, **P<0.01. Difference was analyzed by one-way ANOVA.