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. 2022 Jan 16;18(4):1347–1362. doi: 10.7150/ijbs.67974

Figure 6.

Figure 6

LncRNA-COX2 weakens the progression of epidural fibrosis. (A) Schematic illustrating the timelines for in vivo use of LncRNA-COX2 and decision of experimental end points in the laminectomy model of epidural fibrosis. (B) Cross sections of the vertebral column stained with Masson's trichrome staining to show collagen deposition (blue) and stained with the fibrotic indications. (n = 3 mice per group) at day 7. Scale bars: 200 μm. Higher-power image scale bars: 50 μm. Effect of LncRNA-COX2 on the epidural fibrogenesis initiation reflected by the mRNA expression of fibrotic markers Collagen I (C), α-SMA (D), YAP (E) and Fibronectin (F). In C-F, each symbol represents an individual mouse. *P<0.05. Difference was analyzed by one-way ANOVA.