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. 2022 Jan 16;18(4):1347–1362. doi: 10.7150/ijbs.67974

Figure 7.

Figure 7

LncRNA-COX2 decreases laminectomy-induced epidural scar formation. (A) Schematic illustrating the timelines for in vivo administration of LncRNA-COX2 and determination of experimental end points, and for the final phase in the laminectomy model of epidural fibrosis. (B) Cross sections of the vertebral column stained with Masson's trichrome staining to show collagen deposition (blue) (n = 3 mice per group) at day 28. Scale bar: 200 μm. The effect of epidural scar on spinal cord after oral administration of saline, LV-control or LV- LncRNA-COX2 reflected by (C) mean thickness of epidural scar, (D) relative hydroxyproline content, (E) conus medullaris space area, (F) subarachnoid space area and (G) epidural space area. *P<0.05. **P<0.01. NS means not significant. Difference was analyzed by one-way ANOVA.