. 2022 Mar 5;20:44. doi: 10.1186/s12958-022-00919-0

Table 1.

AKT1, TSC2, mTOR, and S6K expression in patients with premature ovarian insufficiency vs. fertile controls

	POI (n = 74)	FC (n = 56)
Gene	Median (25^th to 75^th percentiles)	Median (25^th to 75^th percentiles)	p^a
FMR1	3.539 (2.487–4.594)	3.400 (2.374–4.373)	0.382
AKT1	4.797 (3.972–5.553)	3.590 (1.724–5.342)	0.009
TSC2	3.678 (2.942–4.077)	2.917 (1.269–3.691)	0.001
mTOR	2.533 (1.819–3.996)	1.856 (0.517–3.255)	0.002
S6K	1.824 (1.564–2.281)	1.538 (0.574–2.029)	0.001

Expression of AKT1, TSC2, mTOR, and S6K (relative gene expression) in peripheral blood of patients with patients with premature ovarian insufficiency and fertile controls. Abbreviations: POI premature ovarian insufficiency, FCs fertile controls. ^aMann-Whitney tests