Table 2. Small blood vessel scores using MMSE-2 scoring in the entire cohort.
Statistical tests showed that the data all conformed to the normal distribution with or without cognitive impairment, and then the homogeneity of variance was further tested. ANOVA analysis was used to conclude that the total CMBs score, total lacunes score, lobar CMBs score, total SVD burden score and total SVD burden score ≥3 was heterogeneity of variance, therefore, Welch’s adjusted unpaired t-test was selected. For others, an unpaired t-test was selected.
| Evaluated by using MMSE-2 | |||||
|---|---|---|---|---|---|
| Without CI | With CI | F | t | p | |
| Total WMH score | 0.39 ± 0.490 | 0.51 ± 0.503 | 3.247 | −1.707 | 0.089 |
| Periventricular WMH | 1.43 ± 0.925 | 1.64 ± 0.954 | 3.247 | −1.599 | 0.111 |
| Deep WMH | 0.39 ± 0.490 | 0.51 ± 0.503 | 0.497 | −1.707 | 0.093 |
| Total CMBs score | 0.60 ± 0.491 | 0.71 ± 0.458 | 12.128 | −1.579 | 0.116 |
| Lobar CMBs | 0.31 ± 0.464 | 0.43 ± 0.499 | 8.485 | −1.737 | 0.085 |
| Deep CMBs | 0.48 ± 0.501 | 0.60 ± 0.494 | 4.822 | −1.693 | 0.094 |
| Subtentorial CMBs | 0.26 ± 0.439 | 0.26 ± 0.444 | 0.034 | −0.093 | 0.926 |
| Total Lacunes score | 0.45 ± 0.499 | 0.68 ± 0.470 | 15.489 | −3.446 | ≤0.001 |
| Total perivascular spaces score | 1.00 ± 0.000 | 1.00 ± 0.000 | |||
| Basal ganglia PVS | 3.11 ± 0.778 | 3.22 ± 0.859 | 3.065 | −0.981 | 0.328 |
| Centrum semiovale PVS | 3.46 ± 0.647 | 3.54 ± 0.670 | 0.030 | −0.896 | 0.371 |
| Hippocampus PVS | 2.32 ± 0.728 | 2.50 ± 0.732 | 0.041 | −1.769 | 0.078 |
| Total SVD burden score | 2.42 ± 1.167 | 2.90 ± 1.009 | 10.248 | −3.192 | <0.01 |
| ≥2 | 3.02 ± 0.850 | 3.17 ± 0.752 | 1.805 | −1.211 | 0.228 |
| ≥3 | 3.56 ± 0.499 | 3.48 ± 0.505 | 0.608 | 0.900 | 0.370 |
Note:
WMH: white matter hyperintensities. CMBs: cerebral microbleeds. PVS: perivascular spaces. SVD: small vessel disease. MMSE: Mini-mental State Examination. CI: cognitive impairment.