Table 6. Joint effect of diabetes and lacunas to cognitive impairment.

Factor 1	Factor 2	Without cognitive impairment	Cognitive impairment
		N	N	Adjusted OR	(95% CI)
Diabetes	Lacuna
(−)	(−)	57	11	1.00	[ref.]
(−)	(+)	38	6	0.818a	[0.279–2.400]
(+)	(−)	29	12	2.144a	[0.844–5.477]
(+)	(+)	31	43	7.188a	[3.250–15.895]
		Synergy index		6.429a	[0.753–54.911]
(−)	(−)	57	11	1.00	[ref.]
(−)	(+)	38	6	0.674b	[0.218–2.081]
(+)	(−)	29	12	1.905b	[0.734–4.944]
(+)	(+)	31	43	6.248b	[2.743–14.230]
		Synergy index		9.059b	[0.316–259.394]
(−)	(−)	57	11	1.00	[ref.]
(−)	(+)	38	6	0.730c	[0.234–2.273]
(+)	(−)	29	12	1.779c	[0.679–4.663]
(+)	(+)	31	43	6.221c	[2.719–14.235]
		Synergy index		10.256c	[0.236–445.414]
(−)	(−)	57	11	1.00	[ref.]
(−)	(+)	38	6	0.754d	[0.242–2.353]
(+)	(−)	29	12	1.807d	[0.688–4.746]
(+)	(+)	31	43	6.411d	[2.785–14.755]
		Synergy index		9.647d	[0.302–308.531]
(−)	(−)	57	11	1.00	[ref.]
(−)	(+)	38	6	0.705e	[0.222–2.241]
(+)	(−)	29	12	1.959e	[0.735–5.221]
(+)	(+)	31	43	7.179e	[3.038–16.965]
		Synergy index		9.301e	[0.442–195.935]
(−)	(−)	57	11	1.00	[ref.]
(−)	(+)	38	6	0.684f	[0.212–2.205]
(+)	(−)	29	12	2.104f	[0.784–5.648]
(+)	(+)	31	43	7.179f	[2.996–17.202]
		Synergy index		7.839f	[0.547–112.447]
(−)	(−)	57	11	1.00	[ref.]
(−)	(+)	38	6	0.629g	[0.190–2.078]
(+)	(−)	29	12	1.978g	[0.724–5.405]
(+)	(+)	31	43	7.084g	[2.836–17.698]
		Synergy index		10.018g	[0.344–291.414]

Notes:

CI, confidence interval; OR, odds ratio; ref, reference.

^aWithout any adjusted.

^bAdjusted for age.

^cAdjusted for sex and age.

^dAdjusted for sex, age, and history of smoking.

^eAdjusted for age, sex, history of smoking, and education.

^fAdjusted for sex, age, smoking status, education, and hyperlipidemia.

^gAdjusted for sex, age, smoking status, education, hyperlipidemia, and hypertension.