KEY RESOURCES TABLE
| REAGENT or RESOURCE | SOURCE | IDENTIFIER |
|---|---|---|
| Antibodies | ||
| anti-Tyrosine hydroxylase (TH) | Novus Biologicals | NB300-109; RRID:AB_350437 |
| anti-Dopamine transporter (DAT) | Sigma | D6944; RRID:AB_1840807 |
| anti-Zrt- And Irt-Like Protein 14 (ZIP14) | Thermo Fisher Scientific | PA5-21077; RRID:AB_11157266 |
| anti-Divalent Metal Transporter 1 (DMT1) | Proteintech | 20507-1-AP; RRID:AB_10694284 |
| anti-Transferrin Receptor 1 (TFR1) | Invitrogen | 13-6800; RRID:AB_2533029 |
| anti-Ferroportin (FPN) | Thermo Fisher Scientific | PA5-64232; RRID:AB_2647507 |
| anti-Astrocyte cell surface antigen-2 (ACSA-2) | Miltenyi Biotec | 130-097-678; RRID:AB_2894998 |
| anti-CD11b | Miltenyi Biotec | 130-126-725 |
| anti-O4 | Miltenyi Biotec | 130-094-543; RRID:AB_2847907 |
| anti-CD31 | Miltenyi Biotec | 130-097-418; RRID:AB_2814657 |
| anti-β-actin-horseradish peroxidase (HRP) | Sigma | A3854; RRID:AB_262011 |
| anti-IL-6 | Thermo Fisher Scientific | P620; RRID:AB_223481 |
| anti-IL-1β | Thermo Fisher Scientific | P420B; RRID:AB_223478 |
| anti-TNF-α | Thermo Fisher Scientific | 14-7423-81; RRID:AB_468491 |
| anti-IgG | Thermo Fisher Scientific | 16-4301-81; RRID:AB_470153 |
| Chemicals, peptides, and recombinant proteins | ||
| MPTP HCl | Sigma Aldrich | M0896 |
| Deferiprone | ApoPharma | N/A |
| Recombinant mouse α-syn protein | Novus Biologicals | NBP2-61595 |
| Critical commercial assays | ||
| eBioscience™ ProcartaPlex Mouse | Thermo Fisher Scientific | EPXR360-26092-901 |
| Cytokine and Chemokine Convenience | ||
| Panel 1A | ||
| QuantiGene 35-plex Panel assay (custom) | Thermo Fisher Scientific | Custom |
| MDA ELISA | Abcam | ab238537 |
| Mouse IL-6 ELISA | Invitrogen | BMS603-2 |
| Experimental models: Organisms/strains | ||
| C57BL6/J Wild-Type | Jackson Labs | 000664 |
| IL-6 knockout | Jackson Labs | 002650 |
| hA53T transgenic | Jackson Labs | 006823 |
| GFAP-IL6 transgenic | Scripps Research Institute | via MTA |