Table 3.

Designing future drug trials targeting appetite loss/anorexia of aging

Target population	Assessment tool of appetite/anorexia	Outcome measures	Study length
Inclusion criteria ≥ 65 years-old Chronic appetite loss (avoid people with acute loss due to infections or others) Reduced food intake Other conditional inclusion criteria Chronic on-going weight loss Exclusion criteria Depression Severe cognitive impairment Dysphagia, dental or oral problems	SNAQ FAACT CNAC Other	Primary Appetite Weight Secondary Physical performance/mobility Muscle strength Quality of life Survival Body composition (eg, lean/fat mass)	Between 3 months (for phase 2 trials) and 12 months (for phase 3 trials, with more difficult-to-change clinical outcomes, such as mobility)