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Celastrol alleviates RV hypertrophy and fibrosis in PAH rats. (A) RV hypertrophy index; (B) Histopathological features of collagen deposition based on Masson staining of heart sections (×40); (C) Quantification of Masson staining; (D), (E) RV mRNA expression of collagen I and collagen III. n=8 for each group. *, P<0.05, **, P<0.01, ***, P<0.001. RV, right ventricle; PAH, pulmonary arterial hypertension. MCT, monocrotaline.
