TABLE 2.

Cox regression for overall survival in patients with T4b disease without metastases, supraclavicular lymph nodes metastases only or distant metastases after unresectable or metastatic diagnosis ^a

Variable	Number of patients	Events	Median OS	Univariable regression		Multivariable regression
				HR (95% CI)	P‐value	HR (95% CI)	P‐value
Type of disease
T4b disease without metastases	146	129	6.3	1.38 (1.05‐1.81)	.019	1.44 (1.04‐1.99)	.028
Supraclavicular lymph nodes metastases only	118	100	11.2	Ref		Ref
Distant metastatic disease	681	671	4.4	1.52 (1.22‐1.90)	< .001	1.42 (1.12‐1.80)	.004

All patients with unresectable (cT4b) or synchronous metastatic esophageal squamous cell carcinoma at primary diagnosis (2015‐2018) or patients with metachronous metastases after primary non‐metastatic diagnosis (2015‐2016) were included.

^a Sex, age, number of comorbidities, tumor location at primary diagnosis, cT stage at primary diagnosis, cN stage at primary diagnosis, tumor differentiation at primary diagnosis, and number of metastatic sites all met the proportional hazard assumptions and the multivariable Cox regression analyses were adjusted for these variables. Type of treatment and performance status did not meet the proportional hazard assumptions and the multivariable model was stratified for these variables.