TABLE 1.
Summary of tumor formation in cervical cancer xenografts
| Cells | Tumor formationa |
|---|---|
| HCK1T tet‐off | |
| ‐tre HPV16E6E7‐MYCT58A – HRASG12V | 8/8 (39) |
| ‐tre HPV16E6E7‐MYCT58A – KRASG12V | 8/8 (59) |
| ‐tre HPV16E6E7‐MYCT58A – KRASG12V + FOXA2 | 8/8 (48) |
| ‐tre HPV16E6E7‐MYCT58A – KRASG12V + SMAD4mi | 5/8 (95) |
| ‐tre HPV16E6E7‐MYCT58A – KRASG12V + SMAD4mi + FOXA2 | 5/8 (100) |
| ‐tre HPV16E6E7‐MYCT58A – KRASG12V (DOX +) | 0/4 (100) |
| HCK1T tet‐off | |
| ‐tre HPV18E6E7‐MYCT58A – KRASG12V | 3/4 (100) |
| ‐tre HPV18E6E7‐MYCT58A – KRASG12V + FOXA2 | 3/4 (100) |
| ‐tre HPV18E6E7‐MYCT58A – KRASG12V + SMAD4mi | 4/4 (100) |
| ‐tre HPV18E6E7‐MYCT58A – KRASG12V + SMAD4mi + FOXA2 | 4/4 (100) |
| ‐tre HPV18E6E7‐MYCT58A – KRASG12V (DOX+) | 0/4 (100) |
Incidence of tumor formation within 100 days of observation period.
a(Number of tumors)/(number of transplantations) are indicated. Mice were killed when the average tumor volume reached >600 mm3. Mice whose tumors did not attain 600 mm3 were killed at day 100 and tumors were collected. Numbers in parentheses indicate the time (d) until mice were killed.