FIGURE 5.

Exosome derived from M1 macrophages inhibits cell viability and promotes cell apoptosis by inhibiting serine/threonine kinase 16 (STK16). (A‐D) STK16 expression in H1975 cells treated with exosomes derived from M0 macrophages (M0‐exo) or M1 macrophages (M1‐exo) with or without 20 μM GW4869. (E) Cell viability, (F, G) apoptosis, and (H, I) expression of p‐AKT1 and AKT1 in H1975 cells treated with M1‐exo and transduced with STK16 expression vector. ***P < .001 compared with control. ^### P < .001 compared with M1‐exo or M1‐exo+Vector