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SARS-2 RBD-directed B cell characteristics
Spleens were harvested on day 42, and SARS-2 RBD-directed IgG+ B cells were isolated via flow cytometry and sequenced.
(A) Abs representative of lineages that were expanded in RBM-focusing cohorts were expressed recombinantly as Fabs, and their binding was characterized using BLI.
(B) Pseudovirus neutralization for these Abs was also characterized.
See also Figure S6).
