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. 2022 Mar 7;38(12):110561. doi: 10.1016/j.celrep.2022.110561

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© 2022 The Author(s)

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Structural characterization of Abs from the RBM-focused immune response

(A) Low-resolution cryo-EM map with a model of Ab20 as Fab (pink) bound to the RBD (blue) with the RBM (gray) shown (the RBD is from PDB: 6VXX). For clarity, only a single RBD and Fab are shown.

(B) Low-resolution cryo-EM map with a model of Ab16 as Fab (pink) bound to the RBD (blue) with the RBM (gray) shown (the RBD is from PDB: 7DX9). For clarity, only a single RBD and Fab are shown.

(C) Model from (B) with docked ACE2 (from PDB: 6M0J).

(D) Cryo-EM map with 3 docked RBDs (blue, with RBMs in gray) from the “3 RBD up” spike in PDB: 7DX9. RBDs are shown as ribbons, and the Fab Ab16 was removed to show its density and the slight outward rotation of the RBD required to better fit the density compared with the docked model.

(E) Interface of the co-crystal structure of the SARS-2 RBD and the Ab17 heavy-chain (yellow) and light-chain (purple) complex.

(F) Surface of the SARS-2 RBD in contact with Ab17 heavy-chain (yellow) and light-chain (purple) residues.

See also Figure S7.