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. 2022 Mar 7;38(12):110561. doi: 10.1016/j.celrep.2022.110561

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© 2022 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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SARS-2 protection studies in K18-hACE2 transgenic mice

(A) Schematic showing the passive transfer and SARS-2 D614G live virus challenge timeline.

(B) Following inoculation with SARS-2 D614G, each mouse was weighed daily. There were 5 mice in each of the 3 cohorts. The mean + SE for the three cohorts is shown at each time point. Cohorts were compared using an ordinary one-way ANOVA with Dunnett’s test of the area under the curve (^∗p < 0.05, ^∗∗p < 0.01).

(C–E) 6 days after inoculation, tissues were harvested, and viral RNA levels in the (C) lungs, (D) heart, and (E) nasal washes were assessed by qRT-PCR RNA. Cohorts were compared using a Kruskal-Wallis test with post hoc analysis using Dunn’s test corrected for multiple comparisons (^∗p < 0.05, ^∗∗p < 0.01).