Table 2.
Drugs acting targeting TS
| Drugs | Status | Diseases | Structures |
|---|---|---|---|
| Raltitrexed | Approved | Chemotherapy drug |
|
| Pemetrexed | Approved | Chemotherapy drug |
|
| Pralatrexate | Approved | Chemotherapy drug | |
| Flucytosine | Approved | Antifungal |
|
| Capecitabine | Approved | Chemotherapy drug |
|
| Gemcitabine | Approved | Chemotherapy drug |
|
| S,S-(2-Hydroxyethyl)Thiocysteine | Approved | Investigational |
|
| Trifluridine | Approved | Antiviral agent |
|
| Fluorouracil | Approved | Anti-metabolites |
|
| Methotrexate | Approved | Anti-metabolites |
|
| ANX-510 | Approved | Folate-based biomodulator drug |
|
| Thymectacin | Approved | Colon cancer |
|
| Tegafur-uracil | Approved | Chemotherapy drug |
|
| 10-Propargyl-5,8-Dideazafolic acid | Approved | Investigational |
|
| (6S)-5,6,7,8-tetrahydrofolic acid | Approved | Investigational |
|
| 5-Fluoro uracil | E. Coli | ||
| 5,10-Methylene-6-Hydrofolic acid | Antineoplastic antimetabolite |
|
|
| 2-(2-chloropyridin-4-yl)-4-methyl-1H-isoindole-1,3(2H)-dione | Investigational |
|
|
| 2-(4-hydroxybiphenyl-3-yl)-4-methyl-1H-isoindole-1,3(2H)-dione | Investigational |
|
|
| 4-(4-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzonitrile | Investigational |
|
|
| 3-Diphenol-6-nitro-3 h-benzo[de]isochromen-1-one | Investigational |
|
|
| Floxuridine | Chemotherapy drug |
|
|
| OSI-7904L | Investigational |
|
|
| 2,4-Diamino-5-phenyl-6-ethylpyrimidine | Investigational |
|
|
|
N-[2-Chloro-5-(trifluoromethyl)phenyl] imidodicarbonimidic diamide |
Investigational |
|
|
|
N-(3,5-dimethoxyphenyl) imidodicarbonimidic diamide |
Investigational |
|
|
| 6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine | Investigational |
|
|
| LY231514 tetra glu | Investigational |
|
|
| l-methionine (S)-S-oxide | Investigational |
|
|
| Tosyl-d-proline | Investigational |
|
|
| N-Carboxymethionine | Investigational |
|
|
| LY341770 | Investigational |
|
|
| N,O-Didansyl-l-Tyrosine | Investigational |
|
|
| SP-876 | Investigational |
|
|
| N-[Tosyl-d-Prolinyl]Amino-Ethanethiol | Investigational |
|
|
| 1,4-Dithiothreitol | Investigational |
|
|
| Sp-722 | Investigational |
|
|
| S,S-(2-Hydroxyethyl)Thiocysteine | Investigational |
|
|
| 4-Chloro-3',3''-dibromophenol-1,8-naphthalein | Investigational |
|
|
| 2-{4-[2-(2-Amino-4-oxo-4,7-dihydro-3 h-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino}-3-methyl-butyric acid | Investigational |
|