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. 2022 Mar 7;49(7):6659–6691. doi: 10.1007/s11033-022-07266-8

Table 3.

Drugs targeted bifunctional DHFR-TS and SHMT

Bifunctional DHFR TS* SHMT
Drugs Status Diseases Structures
Pyrimethamine Antimalarial Levoleucovorin Approved Osteosarcoma graphic file with name 11033_2022_7266_Figcf_HTML.gif
Proguanil Antimalarial Pyridoxal phosphate Approved Active form of vitamin B6 graphic file with name 11033_2022_7266_Figcg_HTML.gif
Sulfadoxine Antimalarial N-Pyridoxyl-Glycine-5-Monophosphate Investigational graphic file with name 11033_2022_7266_Figch_HTML.gif
(6R)-Folinic acid (M) Anticancer graphic file with name 11033_2022_7266_Figci_HTML.gif
Artenimol (c) Antimalarial graphic file with name 11033_2022_7266_Figcj_HTML.gif
Mimosine (M) Antineoplastic graphic file with name 11033_2022_7266_Figck_HTML.gif
Triglu-5-formyl-tetrahydrofolate© Investigational graphic file with name 11033_2022_7266_Figcl_HTML.gif
5-hydroxymethyl-5,6-dihydrofolic acid© Investigational graphic file with name 11033_2022_7266_Figcm_HTML.gif
Tetrahydrofolic acid© Folic acid derivative graphic file with name 11033_2022_7266_Figcn_HTML.gif
Lometrexol (M) Antifolate graphic file with name 11033_2022_7266_Figco_HTML.gif
JPC-2056 Methoxypyrimidine graphic file with name 11033_2022_7266_Figcp_HTML.gif
JPC-2067-B graphic file with name 11033_2022_7266_Figcq_HTML.gif

*Structures mentioned earlier