Figure 3.

Genomic alterations of fibrotic TNBCs

(A) Oncoplot depicting the top 20 most frequently mutated genes and their mutation types per subgroups of fibrosis in TNBC. Different mutation types are shown in different colors and the percentage (%) of patients affected is shown in the paragraph. (B) Comparison of mutation frequency between the high fibrosis group and the no fibrosis group (calculated using Fisher's exact test). Significantly different mutated genes (mean mutation frequency >3% and a false discovery rate [FDR] of <0.05) are highlighted in red. (C) Comparison of the SCNVs between the high fibrosis group and the no fibrosis group. The top plot illustrates the frequency of the amplification (dark red), gain (light red), loss (light blue), and deletion (dark blue) of each gene in each group, and the bottom plot illustrates the –log₁₀ p value of each gene when comparing the frequency of loss or deletion or gain or amplification between the high fibrosis group and the no fibrosis group.