Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 27;2022:7837837. doi: 10.1155/2022/7837837

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Huimin Deng et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Human mesenchymal stem cells (hMSCs) inhibited lipopolysaccharide- (LPS-) induced glycolysis and proinflammatory cytokine production in macrophages. (a) Western blot experiment showed that hMSCs derived from adipose tissue (hADMSCs), bone marrow (hBMMSCs), and umbilical cord (hUCMSCs) inhibited key enzymes involved in glycolysis, including (b) PKM2, (c) HK2, and (d) LDHA. Moreover, the end products of glycolysis decreased, such as (e) lactic acid, as did (f) the consumption of glucose. hADMSCs, hBMMSCs, and hUCMSCs significantly reduced the mRNA expression of (g) interleukin- (IL-) 1β, (h) IL-6, and (i) tumor necrosis factor- (TNF-) α and increased the mRNA levels of (j) Arg1, (k) Ym-1, and (l) CD206 in LPS-treated RAW264.7 cells. All mRNA levels were normalized to the level of β-actin mRNA. Data are expressed as mean ± standard deviation (n = 6 in each group). p values were calculated using one-way ANOVA. ^∗p < 0.05; ^∗∗p < 0.01.