Table 1.
Characteristics of the population and comparison between the genetic status of the cases.
| Controls (n= 34) | CF (n= 17) | p (Controls vs CF) | DF508 homozygous (n= 8) | Other mutations (n= 9) | P (DF508 vs other mutations) | |
|---|---|---|---|---|---|---|
| Age (yrs) | 29.3 (± 4.1) | 29.3 (± 4.2) | NS | 27.1 (± 3.1) | 31 (± 5) | NS |
| Weight (kg) | 61.7 (± 11.7) | 52.7 (± 5.9) | 0.004 | 52.6 (± 6.1) | 52.8 (± 6) | NS |
| BMI (kg/m2) | 23.6 (± 3.8) | 20.3 (± 1.8) | 0.0018 | 20.4 (± 2.2) | 20.2 (± 1.6) | NS |
| History of spontaneous pregnancy | 0.3 (± 0.7) | 0.2 (± 0.4) | NS | 0.1 (± 0.4) | 0.2 (± 0.4) | NS |
| History of ART pregnancy | 0.1 (± 0.4) | 0.1 (± 0.3) | NS | 0.1 (± 0.4) | 0.1 (± 0.3) | NS |
| Pulmonary Surgery | 0.2 (± 0.4) | 0.5 (± 0.5) | 0 (± 0) | 0.0221 | ||
| CFTR modulators | 0.1 (± 0.2) | 0.1 (± 0.4) | 0 (± 0) | NS | ||
| FEV1 (%) | 63.2 (± 18) | 67.1 (± 24.7) | 59.4 (± 7) | NS | ||
| Diabetes | 0.5 (± 0.5) | 0.5 (± 0.5) | 0.4 (± 0.5) | NS | ||
| Exocrine insufficiency | 0.8 (± 0.4) | 1 (± 0) | 0.7 (± 0.5) | NS | ||
| Pseudomonas aeruginosa colonization | 0.9 (± 0.3) | 1 (± 0) | 0.8 (± 0.4) | NS |
Results are expressed as mean ± SD.
NS, non-significant; CFTR, cystic fibrosis transmembrane conductance regulator; ART, assisted reproductive technology; FEV1, forced expiratory volume in 1 second.