FIGURE 1.

Schematic of renal filtration structure and essential slit diaphragm proteins. The left panel shows the glomerular filtration barrier structure in human. The blood is filtered through fenestrated endothelial cells, glomerular basement membrane and slit diaphragm between the podocyte foot processes. The right panel shows the filtration structure in the Drosophila nephrocyte. The hemolymph is filtered through the basement membrane and slit diaphragm located at the opening of the lacunar channels. The core components of the slit diaphragm are highly conserved between fly and human.