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. 2022 Feb 21;10:837828. doi: 10.3389/fcell.2022.837828

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Copyright © 2022 van de Leemput, Wen and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic of slit diaphragm formation and maintenance in Drosophila nephrocytes. The apical polarity Crumbs (Crb) and aPKC complexes are localized at the slit diaphragm and define the apical region of the nephrocyte which is important during slit diaphragm formation. The basolateral Scribble (Scrib) complex localizes to the basal region of the nephrocyte between neighboring slit diaphragms. The clathrin-mediated endocytosis, Rab5-dependent early endosomes, Rab11-dependent recycling endosomes and the exocyst complex are critical for slit diaphragm maintenance. Gapvd1, Vps34 (Pi3K59F), and possibly the Scrib basal polarity complex, positively regulate Rab5-dependent early endosome trafficking. Tbc1d8b negatively regulates the function of Rab11 in slit diaphragm recycling. SD, slit diaphragm; EE, early endosome; and, RE, recycling endosome.