Table 5.
Univariate and multivariate analyses of clinical pregnancies and live births in entire ovarian cycles.
| n | Crude OR | 95% CI | P value | Adjusted OR | 95% CI | P value | |
|---|---|---|---|---|---|---|---|
| Cumulative pregnancy regression a | |||||||
| Age (years) | |||||||
| <35 (Ref) | 8080 | – | – | – | – | – | – |
| 35–39 | 1360 | 0.582 | 0.517–0.656 | <0.001 | 0.718 | 0.627–0.822 | <0.001 |
| ≥40 | 100 | 0.262 | 0.176–0.392 | <0.001 | 0.306 | 0.198–0.473 | <0.001 |
| BMI | |||||||
| ≥25 (Ref) | 1379 | – | – | – | – | – | – |
| <18.5 | 985 | 1.342 | 1.122–1.604 | 0.001 | 1.224 | 1.003–1.494 | 0.046 |
| 18.5–24.9 | 7176 | 1.280 | 1.132–1.447 | <0.001 | 1.233 | 1.075–1.413 | 0.003 |
| Dosage of Gn (IU) | |||||||
| ≥3000 (Ref) | 3082 | – | – | – | – | – | – |
| <2100 | 2812 | 2.385 | 2.124–2.677 | <0.001 | 1.192 | 1.034–1.374 | 0.015 |
| 2100–2999 | 3646 | 1.706 | 1.539–1.890 | <0.001 | 1.138 | 1.012–1.280 | 0.031 |
| Progesterone on the day of the hCG trigger (ng/mL) | |||||||
| ≥1.3 (Ref) | 3456 | – | – | – | – | – | – |
| <0.8 | 2721 | 0.931 | 0.834–1.039 | 0.201 | 1.265 | 1.113–1.437 | <0.001 |
| 0.8–1.29 | 3363 | 1.029 | 0.927–1.143 | 0.592 | 1.219 | 1.083–1.372 | 0.001 |
| Endometrial thickness on the day of the hCG trigger (mm) | |||||||
| <10 (Ref) | 1489 | – | – | – | – | – | – |
| 10–12 | 4872 | 1.384 | 1.225–1.563 | <0.001 | 1.401 | 1.224–1.604 | <0.001 |
| ≥13 | 3179 | 1.746 | 1.530–1.993 | <0.001 | 1.847 | 1.594–2.139 | <0.001 |
| Number of oocytes retrieved | |||||||
| <4 (Ref) | 191 | – | – | – | – | – | – |
| 4–9 | 2110 | 2.380 | 1.747–3.243 | <0.001 | 1.717 | 1.242–2.374 | 0.001 |
| 10–19 | 4968 | 4.985 | 3.680–6.754 | <0.001 | 2.355 | 1.697–3.268 | <0.001 |
| ≥20 | 2271 | 8.228 | 6.002–11.282 | <0.001 | 2.575 | 1.805–3.673 | <0.001 |
| Total number of available embryos for ET | |||||||
| <4 (Ref) | 3088 | – | – | – | – | – | – |
| 4–6 | 4182 | 3.644 | 3.295–4.029 | <0.001 | 2.823 | 2.525–3.157 | <0.001 |
| ≥7 | 2270 | 11.203 | 9.547–13.147 | <0.001 | 7.185 | 5.972–8.645 | <0.001 |
| LH on the day of initiation (mIU/mL) | |||||||
| ≥1.5 (Ref) | 3345 | – | – | – | – | – | – |
| <1 | 2838 | 0.825 | 0.739–0.921 | 0.001 | – | – | 0.679 |
| 1–1.49 | 3357 | 0.864 | 0.777–0.960 | 0.007 | – | – | 0.250 |
| Cumulative live-birth regression b | |||||||
| Age (years) | |||||||
| < 35 (Ref) | 8080 | – | – | – | – | – | – |
| 35–39 | 1360 | 0.484 | 0.431–0.543 | <0.001 | 0.574 | 0.505–0.654 | <0.001 |
| ≥40 | 100 | 0.210 | 0.135–0.327 | <0.001 | 0.252 | 0.158–0.402 | <0.001 |
| BMI | |||||||
| ≥25 (Ref) | 1379 | – | – | <0.001 | – | – | 0.014 |
| < 18.5 | 985 | 1.388 | 1.174–1.640 | <0.001 | 1.161 | 0.961–1.402 | 0.122 |
| 18.5–24.9 | 7176 | 1.318 | 1.173–1.480 | <0.001 | 1.212 | 1.065–1.381 | 0.004 |
| FSH on the day of initiation (mIU/mL) | |||||||
| <1.6 (Ref) | 2772 | – | – | – | – | – | – |
| 1.6–2.59 | 3580 | 0.875 | 0.789–0.970 | 0.011 | 0.904 | 0.808–1.012 | 0.081 |
| ≥2.6 | 3188 | 0.712 | 0.641–0.791 | <0.001 | 0.824 | 0.732–0.928 | 0.001 |
| Dosage of Gn (IU) | |||||||
| ≥3000 (Ref) | 3082 | – | – | – | – | – | – |
| <2100 | 2812 | 2.213 | 1.989–2.462 | <0.001 | 1.138 | 0.998–1.298 | 0.054 |
| 2100–2999 | 3646 | 1.673 | 1.518–1.845 | <0.001 | 1.142 | 1.022–1.276 | 0.019 |
| LH on the day of the hCG trigger (mIU/mL) | |||||||
| < 0.5 (Ref) | 2448 | – | – | – | – | – | – |
| 0.5–0.79 | 3657 | 1.095 | 0.987–1.216 | 0.088 | 1.083 | 0.966–1.215 | 0.171 |
| ≥0.8 | 3435 | 1.132 | 1.018–1.259 | 0.022 | 1.174 | 1.043–1.321 | 0.008 |
| Progesterone on the day of the hCG trigger (ng/mL) | |||||||
| ≥1.3 (Ref) | 3456 | – | – | – | – | – | – |
| < 0.8 | 2721 | 0.947 | 0.855–1.050 | 0.301 | 1.226 | 1.088–1.380 | 0.001 |
| 0.8–1.29 | 3363 | 1.025 | 0.930–1.130 | 0.618 | 1.166 | 1.046–1.300 | 0.005 |
| Endometrial thickness on the day of the hCG trigger (mm) | |||||||
| <10 (Ref) | 1489 | – | – | – | – | – | – |
| 10–12 | 4872 | 1.413 | 1.257–1.588 | <0.001 | 1.413 | 1.243–1.605 | <0.001 |
| ≥13 | 3179 | 1.727 | 1.524–1.957 | <0.001 | 1.768 | 1.542–2.028 | <0.001 |
| Number of oocytes retrieved | |||||||
| <4 (Ref) | 191 | – | – | – | – | – | – |
| 4–9 | 2110 | 2.226 | 1.606–3.084 | <0.001 | 1.572 | 1.118–2.209 | 0.009 |
| 10–19 | 4968 | 4.377 | 3.178–6.028 | <0.001 | 2.079 | 1.475–2.931 | <0.001 |
| ≥20 | 2271 | 6.368 | 4.588–8.839 | <0.001 | 2.058 | 1.428–2.966 | <0.001 |
| Number of available embryos for ET | |||||||
| <4 (Ref) | 3088 | – | – | – | – | – | – |
| 4–6 | 4182 | 3.033 | 2.754–3.340 | <0.001 | 2.452 | 2.202–2.731 | <0.001 |
| ≥7 | 2270 | 7.584 | 6.656–8.642 | <0.001 | 5.381 | 4.598–6.299 | <0.001 |
| LH on the day of initiation (mIU/mL) | |||||||
| ≥1.5 (Ref) | 3345 | – | – | – | – | – | – |
| <1 | 2838 | 0.811 | 0.732–0.899 | <0.001 | – | – | 0.759 |
| 1–1.49 | 3357 | 0.879 | 0.797–0.971 | 0.011 | – | – | 0.495 |
Adjusted by age, BMI, history of ectopic pregnancy, history of non-spontaneous abortion, dosage of Gn, progesterone and endometrial thickness on the day of hCG trigger, number of oocytes retrieved, normal fertilization rate, high-quality embryo rate, and the total number of available embryos for ET.
Adjusted by age, BMI, history of ectopic pregnancy, FSH on the day of initiation, progesterone and LH on the day of the hCG trigger, endometrial thickness on the day of the hCG trigger, number of oocytes retrieved, normal fertilization rate, high-quality embryo rate, and the total number of available embryos for ET.
OR, odds ratio; CI, confidence interval; LH, luteinizing hormone; COS, controlled ovarian stimulation; hCG, human chorionic gonadotrophin; BMI, body mass index; FSH, follicle-stimulating hormone; E2, estradiol.