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. 2022 Feb 21;9:799278. doi: 10.3389/fcell.2021.799278

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Copyright © 2022 Yue, Liu, Zuo, Zhu, Li, Liu, Chen and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The COAD tissues of the low-IC50 group were more like hot tumors. (A) The stromal, immune, and ESTIMATE scores of the low-IC50 group were significantly higher than those of the low-IC50 group. (B) The tumor purity of CC tissue was significantly lower in the low-IC50 group. (C) Comparison of abundance of six kinds of tumor infiltrating immune cells between low- and high-IC50 groups. **p < .01, ***p < .001.