Table 1.

Differentially expressed KEGG pathways between study groups

KEGG Pathway	p-valuea	Benjamini-Hochberg adjusted p-value
Biopsy cohort
Upregulated pathways in the HP-associated gastritis group (vs. healthy stomach)
hsa04672 Intestinal immune network for IgA production	<0.001	<0.001
hsa04640 Hematopoietic cell lineage	<0.001	<0.001
hsa04062 Chemokine signaling pathway	<0.001	<0.001
hsa04145 Phagosome	<0.001	<0.001
hsa04380 Osteoclast differentiation	<0.001	<0.001
hsa04514 Cell adhesion molecules (CAMs)	<0.001	<0.001
hsa04670 Leukocyte transendothelial migration	<0.001	0.001
hsa04662 B cell receptor signaling pathway	<0.001	0.002
hsa04612 Antigen processing and presentation	<0.001	0.002
hsa04650 Natural killer cell mediated cytotoxicity	<0.001	0.003
hsa04620 Toll-like receptor signaling pathway	0.001	0.013
hsa04610 Complement and coagulation cascades	0.003	0.036
hsa04660 T cell receptor signaling pathway	0.003	0.038
hsa04666 Fc gamma R-mediated phagocytosis	0.004	0.039
hsa04664 Fc epsilon RI signaling pathway	0.004	0.039
hsa00500 Starch and sucrose metabolism	0.004	0.041
hsa04210 Apoptosis	0.005	0.048
Upregulated pathways in the gastric cancer group (vs. healthy stomach)
hsa04062 Chemokine signaling pathway	<0.001	0.008
hsa04380 Osteoclast differentiation	<0.001	0.016
hsa04512 ECM-receptor interaction	<0.001	0.020
hsa04670 Leukocyte transendothelial migration	<0.001	0.022
hsa04145 Phagosome	<0.001	0.032
hsa04110 Cell cycle	<0.001	0.034
Surgery cohort
Upregulated pathways in gastric cancer group (vs. adjacent severe gastritis)
hsa04110 Cell cycle	<0.001	<0.001
hsa03030 DNA replication	<0.001	0.002
hsa03040 Spliceosome	<0.001	0.002
hsa03010 Ribosome	<0.001	0.003
hsa03008 Ribosome biogenesis in eukaryotes	<0.001	0.015
hsa04115 p53 signaling pathway	0.001	0.018
hsa03013 RNA transport	0.001	0.018
hsa03050 Proteasome	0.001	0.022
hsa00240 Pyrimidine metabolism	0.003	0.046
Upregulated pathways in the adjacent severe gastritis group (vs. gastric cancer)
hsa00980 Metabolism of xenobiotics by cytochrome P450	<0.001	0.004
hsa00982 Drug metabolism - cytochrome P450	<0.001	0.008
hsa04020 Calcium signaling pathway	<0.001	0.008
hsa04971 Gastric acid secretion	<0.001	0.011
hsa00830 Retinol metabolism	<0.001	0.012

KEGG, Kyoto Encyclopedia of Genes and Genomes.

^ap-values obtained from a two-sample t test.