Table 1.

Properties of tominersen, WVE-120101, and WVE-120102

	Tominersen	WVE-120101 and WVE-120102
Backbone chemistry	Phosphorothioate (PS) and Phosphodiester (PO) linkages	Phosphorothioate (PS) and Phosphodiester (PO) linkages
Wing chemistry	2′-O-methoxyethyl (2′-MOE)	2′-O-methyl (2′-O-Me)
Sequence	ctocoaogTAACATTGACaococoac	WVE-120101 ggocoaocAAGGGCACAGaocououc WVE-120102 guogocoaCACAGTAGATgoaogogg
Stereochemistry	Stereorandom	Stereopure
Number of isomers	8192	1
Selectivity	Nonselective	Selective: targets CAG expansion associated SNPs
Population coverage	100%	WVE-120101: 20–56% WVE-120102: 24–51% Combinatorial use: 36–70% [32]

Lower-case letters indicate ribose nucleosides with 2′ sugar modifications; upper-case letters indicate deoxyribose nucleosides; O indicates phosphodiester (PO) linkage; non-labeled linkages indicate chiral phosphorothioate (PS) linkages; underlined letters indicate single nucleotide polymorphism (SNP)