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. 2022 Feb 21;8:808392. doi: 10.3389/fvets.2021.808392

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Copyright © 2022 Nürnberger, Wagner, Müller, Leiting, Leidolf, Alber, Hamann and Geyer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic and exemplary illustration of the anonymized pedigree, MDR1 genotypes and drug-sensitive phenotypes of the cats analyzed in the present study. Documented drug-sensitivity is indicated by red color for the ivermectin-sensitive female (# 1) and male (# 2) Maine Coon cats. Cats without history of neurological toxicity after ivermectin treatments in the past are indicated in yellow. Within the pedigree, circles represent females and boxes represent males. Individual genotypes are indicated as follows: MDR1(+/+), homozygous wild-type; MDR1(+/-), heterozygous mutant or MDR1(-/-), homozygous mutant for the genotype ABCB11930_1931del TC. Dotted lines were used for cats that were not sampled/genotyped. For better clarity, only a limited number of 41 out of the overall 54 related cats were included in this figure.