FIGURE 3.

Terminals of SARM1 KO sensory cutaneous axons exhibit more complex types of morphology than those of WT axons in vivo. (A) Graph of the intra-epidermal nerve fiber density in WT and SARM1 KO skin. n = number of mice (120–127 days of age). (B) Examples of WT and SARM1 KO skin sections stained with anti-PGP9.5 used to obtain the intra-epidermal nerve fiber density measurements presented in (A). (C) Histogram of the number of branches present along the distal 50 microns of sensory fibers. A value of 0 reflects a fiber with no branches and only its terminus. Arrowheads denote the medians. (D) Examples of the morphology of the termini of nerve fibers in WT and SARM1 KO samples.