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CRISPR delivery strategies to the skin. (a) Ex vivo delivery strategy involves deriving patient skin stem cells, treating with CRISPR/Cas + sgRNA against the targeted gene, and reintegrating the corrected skin stem cells into patients. (b) Effective in vivo delivery strategies for CRISPR may include hollow, dissolvable microneedles that penetrate the epidermis, hypodermic needles, and phage delivery (for bacterial infection applications). sgRNA, short guide RNA.
