FIG. 14.

Summary of modulated signal transduction pathways and host cell responses identified during L. monocytogenes infection of murine bone marrow-derived macrophages, murine P388D₁ and J774 cell line macrophages, human Caco-2 and HeLa epithelial cells, mouse dendritic cells, and human umbilical vein endothelial cells. Abbreviations: aSMase, acidic sphingomyelinase; gC1q-R, complement C1q receptor; Hsp70, heat shock protein 70; Hsp90, heat shock protein 90; HSPG-R, HSPG receptor; ICAM-1, intercellular adhesion molecule 1; IFN-γR, IFN-γ receptor; IPx, inositolphosphates; LTA, lipoteichoic acid; MEK-1, mitogen-activated protein kinase kinase 1; Met, receptor tyrosine kinase for HGF; MKP-1, mitogen-activated protein kinase phosphatase 1; PAF, platelet-activating factor; PGI₂, prostaglandin I₂; PIP2, phosphatidylinositol-(3,4)-bisphosphate; PIP3, phosphatidylinositol-(3,4,5)-trisphosphate; PI-PLC, phosphatidylinositol-specific phospholipase C; SR, scavenger receptor; TNF-RI, TNF receptor type 1; VCAM-1, vascular cell adhesion molecule-1. Reproduced with modifications from reference 357 with permission of Elsevier Science.