Table 1.
Correlation Analysis Between AGT and Related Genes and Markers of Immune Cells in TIMER
| Description | Gene Markers | None | Purity | ||||
|---|---|---|---|---|---|---|---|
| R | P value | P Star | R | P value | P Star | ||
| B cell | CD19 | 0.24 | 7.5E-07 | *** | 0.237 | 2.9E-06 | *** |
| CD79A | 0.208 | 2.1E-05 | *** | 0.205 | 6.0E-05 | *** | |
| CD8+ T cell | CD8A | 0.056 | 2.6E-01 | - | 0.063 | 2.2E-01 | - |
| CD8B | 0.113 | 2.1E-02 | * | 0.124 | 1.6E-02 | * | |
| CD4+ T cell | CD4 | 0.182 | 1.9E-04 | *** | 0.183 | 3.3E-04 | *** |
| M1 macrophage | NOS2 | 0.116 | 1.8E-02 | * | 0.102 | 4.7E-02 | * |
| IRF5 | 0.090 | 6.6E-02 | - | 0.091 | 7.7E-02 | - | |
| PTGS2 | 0.086 | 7.9E-02 | - | 0.078 | 1.3E-01 | - | |
| M2 macrophage | CD163 | 0.010 | 4.2E-02 | * | 0.087 | 9.0E-02 | - |
| VSIG4 | 0.094 | 5.5E-02 | - | 0.087 | 9.1E-02 | - | |
| MS4A4A | 0.132 | 7.0E-03 | ** | 0.125 | 1.5E-02 | * | |
| Neutrophil | CEACAM8 | 0.080 | 1.0E-01 | - | 0.085 | 9.8E-02 | - |
| ITGAM | 0.123 | 1.2E-02 | * | 0.115 | 2.6E-02 | * | |
| CCR7 | 0.283 | 5.1E-09 | *** | 0.294 | 5.6E-09 | *** | |
| Dendritic cell | HLA-DPB1 | 0.016 | 7.5E-01 | - | 0.009 | 8.6E-01 | - |
| HLA-DQB1 | −0.053 | 2.8E-01 | - | −0.072 | 1.6E-01 | - | |
| HLA-DRA | −0.067 | 1.8E-01 | - | −0.070 | 1.7E-01 | - | |
| HLA-DPA1 | −0.015 | 7.5E-01 | - | −0.022 | 6.8E-01 | - | |
| CD1C | 0.365 | 1.5E-14 | *** | 0.371 | 7.6E-14 | *** | |
| NRP1 | 0.268 | 3.2E-08 | *** | 0.249 | 9.4E-07 | *** | |
| ITGAX | 0.110 | 2.5E-02 | * | 0.085 | 9.8E-02 | - | |
| Monocyte | CD86 | 0.083 | 9.2E-02 | - | 0.066 | 2.0E-01 | - |
| CD115(CSF1R) | 0.261 | 7.5E-08 | *** | 0.243 | 1.7E-06 | *** | |
| TAM | CCL2 | 0.203 | 3.2E-05 | *** | 0.177 | 5.4E-04 | *** |
| CD68 | 0.159 | 1.2E-03 | ** | 0.136 | 8.0E-03 | ** | |
| IL10 | 0.145 | 3.1E-03 | ** | 0.120 | 1.9E-02 | * | |
| Th1 cell | T‐bet (TBX21) | 0.025 | 6.1E-01 | - | 0.023 | 6.6E-01 | - |
| STAT4 | 0.201 | 3.7E-05 | *** | 0.201 | 7.9E-05 | *** | |
| STAT1 | −0.070 | 1.5E-01 | - | −0.075 | 1.4E-01 | - | |
| TNF-α (TNF) | −0.030 | 5.4E-01 | - | −0.043 | 4.0E-01 | - | |
| Th2 cell | STAT6 | 0.193 | 7.3E-05 | *** | 0.190 | 2.0E-04 | *** |
| STAT5A | 0.136 | 5.6E-03 | ** | 0.144 | 5.1E-03 | ** | |
| IL13 | 0.018 | 7.2E-01 | - | 0.009 | 8.6E-01 | - | |
| Tfh cell | BCL6 | 0.117 | 1.7E-02 | * | 0.109 | 3.4E-02 | * |
| IL21 | −0.035 | 4.7E-01 | - | −0.042 | 4.1E-01 | - | |
| Th17 cell | STAT3 | 0.179 | 2.5E-04 | *** | 0.174 | 6.4E-04 | *** |
| IL17A | 0.069 | 1.6E-01 | - | 0.068 | 1.9E-01 | - | |
| Treg | FOXP3 | 0.175 | 3.5E-04 | *** | 0.176 | 5.7E-04 | *** |
| CCR8 | 0.179 | 2.5E-04 | *** | 0.170 | 8.9E-04 | *** | |
| STAT5B | 0.354 | 1.4E-13 | *** | 0.342 | 7.2E-12 | *** | |
| TGFβ (TGFB1) | 0.232 | 1.8E-06 | *** | 0.206 | 5.2E-05 | *** | |
| T cell exhaustion | PD-1 (PDCD1) | −0.006 | 9.0E-01 | - | 0.001 | 9.9E-01 | - |
| CTLA4 | −0.041 | 4.1E-01 | - | −0.043 | 4.1E-01 | - | |
| LAG3 | −0.059 | 2.3E-01 | - | −0.054 | 2.9E-01 | - | |
| TIM-3 (HAVCR2) | 0.036 | 4.6E-01 | - | 0.023 | 6.5E-01 | - | |
| NK cell | KIR2DL1 | −0.053 | 2.9E-01 | - | −0.06 | 2.5E-01 | - |
| KIR2DL3 | −0.007 | 1.5E-01 | - | −0.009 | 6.7E-01 | - | |
| KIR2DL4 | −0.207 | 2.1E-05 | *** | −0.210 | 3.9E-05 | *** | |
| KIR3DL1 | −0.070 | 1.5E-01 | - | −0.081 | 1.1E-01 | - | |
| KIR3DL2 | −0.063 | 2.0E-01 | - | −0.078 | 1.3E-01 | - | |
| KIR3DL3 | −0.091 | 6.4E-02 | - | −0.018 | 2.2E-02 | - | |
| KIR2DS4 | −0.105 | 3.2E-02 | * | −0.108 | 3.6E-02 | * | |
Notes: P-value Significant Codes: - P≥0.05, * P<0.05, ** P<0.01, *** P<0.001.