Skip to main content
. 2022 Feb 21;13:837497. doi: 10.3389/fimmu.2022.837497

Figure 6.

Figure 6

Therapeutic administration of baicalein rescues retinal ganglion cells (RGCs) and visual functions in retinal I/R mice model. (A) Representative immunofluorescence photomicrographs of BRN-3a-labeled RGCs (red) and (B) quantification of surviving RGCs in whole-mounted retina from normal mice and vehicle or 100 μM baicalein (Ba)-treated mice at 4 weeks post-I/R injury. Scale bar = 20 μm. Representative waveforms (C) and quantification (D) of pSTR in vehicle or 100 μM baicalein-treated mice at 0, 1, and 4 weeks post-I/R injury. Line color: black = baseline, blue = I/R + 100 μM Ba, and gray = I/R + Veh. Spatial vision of (E) visual contrast sensitivity and (F) visual acuity from vehicle or 100 μM baicalein-treated mice at 1 and 4 weeks post-I/R injury were shown. N = 8–9/group. Data were presented as mean  ± SEM. Each dot represented individual replicates. ns, non-significant difference; *P < 0.05, **P < 0.01, ***P < 0.001, two-way ANOVA with Šídák’s multiple comparisons test.