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. 2021 Dec 7;122(3):329–335. doi: 10.1055/a-1715-5960

Table 4. Last day of DOAC intake before an elective intervention: day 0 is the day of surgery/procedure (modified from Steffel et al, 1 EHRA Practical Guide) .

Dabigatran Apixaban–rivaroxaban–edoxaban
Low bleeding risk High bleeding risk Low bleeding risk High bleeding risk
eGFR ≥ 80 mL/min Day 2 Day 3 Day 2 Day 3
eGFR = 50–80 mL/min Day 2/3 (>36 h) Day 4 Day 2 Day 3
eGFR = 30–50 mL/min Day 3 Day 5 Day 2 Day 3
eGFR = 15–30 mL/min Contraindicated Contraindicated Day 2/3 (>36 h) Day 3

Abbreviations: eGFR, estimated glomerular filtration rate; h, hour; min, minute.